Vernon S, Voet R L, Naeim F, Waisman J
Cancer. 1979 Oct;44(4):1273-9. doi: 10.1002/1097-0142(197910)44:4<1273::aid-cncr2820440416>3.0.co;2-x.
A case of malignant lymphoma with vacuolated cells is presented and, as with two other recent reports, is of the nodular poorly differentiated lymphocytic type. This form of malignant lymphoma presumably is composed of neoplastic B lymphocytes, which produce intracellular immunoglobulins or fractions thereof, corresponding to various cellular vacuoles and inclusions. The vacuolated appearance of the neoplastic cells simulates mucinous or "signet ring" adenocarcinoma, which may be excluded by clinical, routine microscopic, histochemical, immunologic, and electron microscopic observations.
本文报告一例伴有空泡细胞的恶性淋巴瘤，与最近的另外两篇报道一样，属于结节性低分化淋巴细胞型。这种恶性淋巴瘤形式可能由肿瘤性B淋巴细胞组成，这些细胞产生细胞内免疫球蛋白或其片段，对应于各种细胞空泡和包涵体。肿瘤细胞的空泡状外观类似于黏液性或“印戒”腺癌，而临床、常规显微镜检查、组织化学、免疫学和电子显微镜观察可排除这种情况。
