Mika H, Wissen-Siegert I
Laryngol Rhinol Otol (Stuttg). 1983 Jun;62(6):239-43.
16 patients with recurrent or metastatic carcinomas of the upper respiratory and digestive tract underwent a total of 55 courses of chemotherapy with Cisplatin and Bleomycin. The cytostatic treatment was performed under outpatient conditions. 0.75 mg./kg. Cisplatin was administered at intervals of 5-8 weeks. In addition, 15 mg. Bleomycin was administered weekly. Hydratation and diuresis were forced by 1000 ml. 0,9% NaCl solution and 1000 ml. levulose 5% with potassium substitution and 250 ml. mannitol 10% after an initial injection of 2 ml. Furosemid. The treatment was generally well tolerated. A nausea lasting 1-3 days was observed after Cisplatin application. Remission of tumours, stopping of tumour progression and a reduction of pain was achieved. The "performance status" was maintained. In 6 cases there was no effect.
16例上呼吸道和消化道复发或转移性癌患者共接受了55个疗程的顺铂和博来霉素化疗。细胞抑制治疗在门诊条件下进行。顺铂按0.75毫克/千克给药，间隔5至8周。此外，每周给予15毫克博来霉素。在首次注射2毫升速尿后，通过1000毫升0.9%氯化钠溶液、1000毫升含钾替代物的5%果糖溶液和250毫升10%甘露醇进行强制水化和利尿。治疗一般耐受性良好。应用顺铂后观察到持续1至3天的恶心。实现了肿瘤缓解、肿瘤进展停止和疼痛减轻。“身体状况”得以维持。6例无效。
