Schröder M, Stennert E, von Heyden H W, Scherpe A
HNO. 1984 Jun;32(6):245-8.
28 patients with recurrent squamous cell carcinoma of the Head and Neck underwent consecutive chemotherapy. Two different regimens were used: cis-platinum plus bleomycin and methotrexate plus vindesine. The former seemed to produce a better response to the latter, but neither differed in its influence on survival. Those patients in whom further radiation therapy or surgery was possible had the longest survival times. Two out of 28 patients who had surgery are still alive 36 months later. The indications for consecutive chemotherapy for recurrent squamous cell carcinoma ought to take into account the age and general condition of the patient, the extent of the recurrence and the possibility of further therapeutic measures.
28例复发性头颈部鳞状细胞癌患者接受了序贯化疗。采用了两种不同的治疗方案：顺铂加博来霉素和甲氨蝶呤加长春地辛。前者似乎比后者产生更好的反应，但两者对生存率的影响并无差异。那些有可能进一步接受放疗或手术的患者生存时间最长。28例接受手术的患者中有2例在36个月后仍然存活。复发性鳞状细胞癌序贯化疗的适应证应考虑患者的年龄和一般状况、复发程度以及进一步治疗措施的可能性。
