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[用于测定前列腺肿瘤和前列腺结节性增生中雄激素受体的天然配体与合成配体的比较]

[Comparison of natural and synthetic ligands for determining androgen receptors in prostatic tumors and prostatic nodular hyperplasia].

作者信息

Kushlinskiĭ N R, Bassalyk L S, Degtiar' V G

出版信息

Med Radiol (Mosk). 1983 Aug;28(8):13-6.

PMID:6193390
Abstract

No difference was found in the values of the equal constants of dissociation and the number of sites specifically binding [3H] DHT and [3H] R1881 in the cytosols of tumor cells and human prostatic nodular hyperplasia. The above data suggest that in the determination of cytoplasmic androgen receptors in healthy and tumorous tissues of the target organs one can use both natural (DHT) and synthetic (R1881) steroids precipitating the hormone-receptor complex with protamin sulphate.

摘要

在肿瘤细胞和人前列腺结节性增生的胞质溶胶中,解离平衡常数的值以及特异性结合[3H]双氢睾酮(DHT)和[3H]R1881的位点数量均未发现差异。上述数据表明,在测定靶器官健康组织和肿瘤组织中的细胞质雄激素受体时,可以使用天然(DHT)和合成(R1881)类固醇,二者均可与硫酸鱼精蛋白沉淀激素-受体复合物。

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