Holter W, Morling N
Tissue Antigens. 1983 Jul;22(1):42-8. doi: 10.1111/j.1399-0039.1983.tb01164.x.
The influence in primary mixed lymphocyte culture reaction (MLR) of a primed lymphocyte typing (PLT) defined non-HLA-D/DR determinant, EP1, was investigated. In primary MLR between HLA-D/DR compatible lymphocytes, the response of the lymphocytes from 14 EP1-negative HLA-D/DR heterozygous individuals towards two EP1-positive homozygous typing cells (HTCs) was on an average approximately 35% higher than the response towards two EP1-negative HTCs (P less than 0.01). The strength of the MLR between lymphocytes from 25 EP1-negative and 10 EP1-positive individuals matched for two HLA-D/DR antigens was investigated. The average responses of EP1-negative lymphocytes against EP1-positive lymphocytes were approximately 40% higher than the average responses against EP1-negative lymphocytes (P less than 0.01). These data indicate that the PLT defined determinant EP1 causes stimulation in primary MLR.
研究了由混合淋巴细胞分型（PLT）定义的非HLA - D/DR决定簇EP1对初次混合淋巴细胞培养反应（MLR）的影响。在HLA - D/DR相容淋巴细胞之间的初次MLR中，14名EP1阴性的HLA - D/DR杂合个体的淋巴细胞对两个EP1阳性纯合分型细胞（HTC）的反应平均比对两个EP1阴性HTC的反应高约35%（P小于0.01）。研究了25名EP1阴性和10名EP1阳性个体的淋巴细胞之间的MLR强度，这两组个体在两个HLA - D/DR抗原上相匹配。EP1阴性淋巴细胞对EP1阳性淋巴细胞的平均反应比对EP1阴性淋巴细胞的平均反应高约40%（P小于0.01）。这些数据表明，由PLT定义的决定簇EP1在初次MLR中引起刺激作用。
