Jaworkowsky L I, Solovey D Y, Rhausova L Y, Udris O Y
Folia Haematol Int Mag Klin Morphol Blutforsch. 1983;110(3):395-401.
In a prospective 11 year-study 53 patients with cytopenias have been followed from the first appearance of haematological abnormalities to death. In 39 patients (group A) the diagnosis of hypoplastic anaemia has been confirmed on autopsy, in 24 (group B) the diagnosis of acute leukemia has been made clinically and/or on autopsy. In 13 patients of group B a monocytosis exceeding 300 cells/microliters could be found at various times before death (4 to 108 months). Patients affected with monocytosis has a survival time being 4 times longer than that of others. Thus, a long term survey and monocyte counting in patients with cytopenias of unknown origin may be of diagnostic and prognostic value.
在一项为期11年的前瞻性研究中，对53例血细胞减少症患者从血液学异常首次出现直至死亡进行了随访。39例患者（A组）经尸检确诊为再生障碍性贫血，24例患者（B组）临床和/或尸检诊断为急性白血病。B组中有13例患者在死亡前不同时间（4至108个月）可发现单核细胞增多超过300个/微升。单核细胞增多的患者生存时间比其他患者长4倍。因此，对不明原因血细胞减少症患者进行长期观察和单核细胞计数可能具有诊断和预后价值。
