Smadja N, Krulik M, Audebert A A, Brissaud P, Debray J
Sem Hop. 1983 Jun 9;59(23):1729-35.
The authors present 7 cases of preleukemic state and/or acute leukemia following the treatment of a first malignancy (3 malignant lymphomas, 3 epithelial cancers and one polycythemia vera). A preleukemic state was found in all patients. In 6 cases it was followed by an acute non-lymphoblastic leukemia which was rapidly fatal; in one case, death occurred during the preleukemic phase. A karyotype was prepared during the preleukemic phase in 6 out of 7 patients and in 4 out of 6 during the leukemia. Karyotypes prepared during the preleukemic state presented at least one of the abnormalities which are characteristic of secondary hematopoietic disorders: -5/5q; -7/7q; involvement of 17. The same major clone was found in 3 of the 6 patients who were karyotyped during the acute leukemic phase. These karyotype abnormalities are not only characteristic of secondary acute leukemias but also of secondary dysmyelopoietic syndromes.
作者报告了7例在治疗首例恶性肿瘤（3例恶性淋巴瘤、3例上皮癌和1例真性红细胞增多症）后出现白血病前期状态和/或急性白血病的病例。所有患者均发现有白血病前期状态。其中6例随后发展为急性非淋巴细胞白血病，且病情迅速恶化；1例在白血病前期阶段死亡。7例患者中有6例在白血病前期阶段进行了核型分析，6例中的4例在白血病阶段进行了核型分析。白血病前期状态时制备的核型显示出至少一种继发性造血系统疾病的特征性异常：-5/5q；-7/7q；17号染色体受累。在急性白血病阶段进行核型分析的6例患者中，有3例发现了相同的主要克隆。这些核型异常不仅是继发性急性白血病的特征，也是继发性骨髓发育异常综合征的特征。
