Watson D, Pow M, Ellam A, Costeloe K
J Epidemiol Community Health. 1983 Sep;37(3):221-5. doi: 10.1136/jech.37.3.221.
An evaluation of voluntary prenatal screening for neural tube defects with serum alphafetoprotein (s-AFP) is presented. During a three year period, there were 52 fetuses with neural lesions. Of 46 mothers who bore a fetus with an open neural lesion, 25 were detected, of whom 23 agreed to the termination of their pregnancies. An unscreened group of 2331 mothers (17% of all deliveries) produced 14 fetuses with neural tube defects, an incidence of 6.0 per 1000, 1.8 times the incidence (3.3 per 1000) in the screened group. Pitfalls occurring in the assessment of hyper-alphafetoproteinemia included inaccurate gestational dating and allowance for excessive body weight. The results of a robust AFP-NTD screening programme supported in selected cases by ultrasonar visualisation of the spine argue for its continuance in this district.
本文介绍了一项利用血清甲胎蛋白（s-AFP）进行神经管缺陷自愿产前筛查的评估。在三年期间，有52例胎儿患有神经病变。在46例怀有开放性神经病变胎儿的母亲中，有25例被检测出来，其中23例同意终止妊娠。一组未经筛查的2331名母亲（占所有分娩的17%）产下了14例神经管缺陷胎儿，发病率为每1000例中有6.0例，是筛查组发病率（每1000例中有3.3例）的1.8倍。评估甲胎蛋白血症过高时出现的问题包括孕周计算不准确和对体重过重的考虑。一项强有力的甲胎蛋白-神经管缺陷筛查计划的结果，在某些情况下通过脊柱超声可视化得到支持，表明该计划应在该地区继续实施。
