Paolino E, Monetti V C, Granieri E, Boldrini P
J Neurol. 1983;230(1):37-41. doi: 10.1007/BF00313595.
Neurological complications following vascular thrombotic crises are frequent and occur in sickle cell anaemia and its variants, but are less well recognized in thalassaemias. A case of beta-thalassaemia major is reported complicated by an ischaemic lesion involving the right cerebellar hemisphere. The probable pathogenesis is considered and the literature on the matter briefly reviewed. In agreement with other reports, the interference of risk factors provided by or occurring in association with multiple blood-transfusions is hypothesized. Consequently, caution is recommended in giving large blood-transfusions to thalassaemic patients.
血管血栓形成危象后的神经并发症很常见，发生于镰状细胞贫血及其变体中，但在地中海贫血中认识较少。本文报道了1例重型β地中海贫血合并右小脑半球缺血性病变的病例。文中探讨了可能的发病机制，并简要回顾了相关文献。与其他报道一致，推测多次输血所带来的或与之相关的危险因素的干扰作用。因此，建议在给地中海贫血患者大量输血时要谨慎。
