Chaudhury S, Chaudhury L, Sarkar P K
Brain Res. 1983 Sep;285(3):291-5. doi: 10.1016/0165-3806(83)90026-3.
In organ cultures of embryonic chick brain, tri-iodothyronine is shown to elicit an age-dependent stimulation of the synthesis of tubulin. In cultures of brains from 8-day embryos where the response is maximal, a 70-100% increase in the rate of synthesis of tubulin is elicited by T3 within 2 h. The stimulatory response is dose-dependent, requires transcription, and is temporally coincident with the early phase of the normal ontogenic rise in level of tubulin and of intense neuronal differentiation in the embryonic chick brain. The overall results indicate the involvement of T3 in regulating the biogenesis of tubulin in the developing brain.
在鸡胚脑器官培养中，已表明三碘甲状腺原氨酸能引发对微管蛋白合成的年龄依赖性刺激。在来自8天胚胎的脑培养物中，反应最为强烈，三碘甲状腺原氨酸在2小时内可使微管蛋白合成速率提高70%-100%。这种刺激反应是剂量依赖性的，需要转录，并且在时间上与鸡胚脑中微管蛋白水平正常个体发育升高以及强烈神经元分化的早期阶段相一致。总体结果表明，三碘甲状腺原氨酸参与调节发育中脑内微管蛋白的生物合成。
