Velasco F, Velasco M, Romo R
Electroencephalogr Clin Neurophysiol. 1983 Nov;56(5):521-7. doi: 10.1016/0013-4694(83)90237-7.
Nine 'encéphale isolé' cats had 'push-pull' perfusions of pentylenetetrazol (PTZ) in various loci of the brain stem, while the EEG from the right and left motor cortices, EMG from neck muscles, ocular movements and clinical changes were recorded. Perfusions in the rostral MRF induced bilateral rhythmic paroxysmal EEG discharges and myoclonic twitching of neck and head, more prominent in the muscles contralateral to the perfused side. PTZ in the caudal MRF induced tonic-clonic paroxysmal EEG discharges and EMG seizures, similar to those seen when PTZ is injected systemically. Perfusion in the PRF induced EEG spindle bursts, muscular hypotonia and myosis. When perfusion in the MRF inducing rhythmic paroxysmal EEG discharges and myoclonic twitching was followed by perfusion in the PRF, the EEG discharges were not modified, but the myoclonic movements were abolished. Perfusions outside the MRF and PRF did not produce obvious changes other than tonic gaze deviation to the contralateral side or nystagmus. The results suggest that PTZ has a differential effect in various structures of the CNS, producing primary generalized convulsive seizures when acting directly on the MRF.
对9只“孤立脑”猫在脑干的不同部位进行了戊四氮（PTZ）的“推-拉”灌注，同时记录左右运动皮层的脑电图、颈部肌肉的肌电图、眼球运动和临床变化。在延髓头端网状结构（MRF）进行灌注时，诱发双侧节律性阵发性脑电图放电以及颈部和头部的肌阵挛抽搐，在灌注侧对侧的肌肉中更为明显。在延髓尾端网状结构注入PTZ诱发强直性阵挛性阵发性脑电图放电和肌电图癫痫发作，类似于全身注射PTZ时所见。在脑桥网状结构（PRF）进行灌注诱发脑电图纺锤波暴发、肌肉张力减退和瞳孔缩小。当在MRF进行灌注诱发节律性阵发性脑电图放电和肌阵挛抽搐后再在PRF进行灌注时，脑电图放电没有改变，但肌阵挛运动消失。在MRF和PRF以外的部位进行灌注，除了向对侧的强直性凝视偏斜或眼球震颤外，没有产生明显变化。结果表明，PTZ在中枢神经系统的不同结构中有不同作用，直接作用于MRF时会产生原发性全身性惊厥发作。
