Bischoff P M, Wajer S D, Flower R W
Graefes Arch Clin Exp Ophthalmol. 1983;220(6):257-63. doi: 10.1007/BF00231352.
It has been suggested that the tunica vasculosa lentis of newborn mice undergoes vasoproliferation after oxygen exposure and might be used as an experimental model for intraocular neovascularization. A scanning electron microscopic technique which provides visualization of the entire hyaloid vascular system was used to study its response in mice exposed to various gas mixtures (70% O2/30% N2, 10% CO2/90% air, 10% CO2/70% O2/20% N2). Marked differences were found between hyaloid regression in gas exposed mice compared to air control mice, but no evidence of neovascularization was found in any group. The data support the possibility that changes in the hyaloid may be the consequence of the hydrostatic coupling which exists between this atrophic, possibly flow-resistant vasculature and the developing retinal vasculature whose blood flow characteristics are significantly altered by exposure to CO2 and O2.
有人提出，新生小鼠的晶状体血管膜在暴露于氧气后会发生血管增殖，可能被用作眼内新生血管形成的实验模型。一种能够可视化整个玻璃体血管系统的扫描电子显微镜技术被用于研究其在暴露于各种气体混合物（70% O₂/30% N₂、10% CO₂/90% 空气、10% CO₂/70% O₂/20% N₂）的小鼠中的反应。与空气对照小鼠相比，在暴露于气体的小鼠中发现玻璃体退化存在显著差异，但在任何组中均未发现新生血管形成的证据。这些数据支持这样一种可能性，即玻璃体的变化可能是这种萎缩性、可能具有抗血流性的脉管系统与发育中的视网膜脉管系统之间存在的流体静力耦合的结果，而视网膜脉管系统的血流特征会因暴露于 CO₂ 和 O₂ 而发生显著改变。
