Love G L, Daroca P J
Hum Pathol. 1983 Nov;14(11):1004-6. doi: 10.1016/s0046-8177(83)80181-6.
A 60-year-old man developed a widely metastatic spindle cell neoplasm with admixed osteoclast-like giant cells indistinguishable from malignant giant cell tumor of soft parts. Autopsy revealed a bronchogenic sarcomatoid squamous cell carcinoma that was the primary source of the sarcomatoid metastases. The osteoclast-like giant cells in the metastatic lesions were negative for lysozyme on immunoperoxidase staining. This finding suggested that the multinucleated giant cells were not formed as a cellular response to hemorrhage or to cellular debris induced by the tumor. Extraosseous neoplasms with osteoclast-like giant cells are rare neoplasms that may occur in a variety of organs. This case is the second reported case of a primary neoplasm in the lung that contained these osteoclast-like giant cells. These tumors may cause considerable diagnostic confusion.
一名60岁男性发生了广泛转移的梭形细胞肿瘤，其中混有破骨细胞样巨细胞，与软组织恶性巨细胞瘤难以区分。尸检显示支气管源性肉瘤样鳞状细胞癌是肉瘤样转移灶的主要来源。转移灶中的破骨细胞样巨细胞免疫过氧化物酶染色溶菌酶呈阴性。这一发现提示多核巨细胞并非作为对肿瘤引起的出血或细胞碎片的细胞反应而形成。伴有破骨细胞样巨细胞的骨外肿瘤是罕见肿瘤，可发生于多种器官。该病例是第二例报道的肺部原发性肿瘤含有这些破骨细胞样巨细胞。这些肿瘤可能导致相当大的诊断困惑。
