Roberts M P, Falvey E, Calvet J P, Pederson T
J Mol Biol. 1983 Oct 5;169(4):975-82. doi: 10.1016/s0022-2836(83)80146-6.
A beta-globin gene probe containing 5' flanking DNA hybridizes to a small nuclear RNA from Friend erythroleukemia cells, which was subsequently identified as 4.5 S RNA. This hybridization is shown to reflect complementarity between the Alu consensus region of 4.5 S RNA and the DNA sequence between nucleotides -33 and -48 from the beta-globin gene transcription initiation site.
一个包含5'侧翼DNA的β-珠蛋白基因探针与来自弗氏红白血病细胞的一种小核RNA杂交,该小核RNA随后被鉴定为4.5S RNA。这种杂交表明反映了4.5S RNA的Alu共有区域与β-珠蛋白基因转录起始位点核苷酸-33至-48之间的DNA序列的互补性。