Fink R, Höche D, Wutke K
Folia Haematol Int Mag Klin Morphol Blutforsch. 1983;110(4):517-25.
Although the worst prognosis among acute forms of leukemia is persistently attributed to the blast crisis of chronic myeloid leukemia, a therapeutic nihilism seems to us to be unreasonable. Even in the developing stage of a blast crisis we consider an aggressive chemotherapy to be justified particularly in younger patients. In this connection, value and necessity of supporting of therapy are especially emphasized. Remissions can be achieved in about one third of patients during the blast crisis of CML. As in other forms of tumour therapy, the initial status, age, and secondary diseases have to be taken into account and a careful, individual therapy planning has to be made. For the future there is the hope that the increasing possibilities of differentiating blasts will allow more systematic therapeutic conclusions to be made. According to the present knowledge the greatest hopes for achieving long-term remissions or even healings can, in our opinion, be expected by bone-marrow transplantation.
尽管急性白血病最糟糕的预后一直被认为是慢性粒细胞白血病的急变期所致，但在我们看来，治疗上的虚无主义是不合理的。即使在急变期的发展阶段，我们认为积极的化疗对于年轻患者尤其合理。在这方面，尤其强调支持治疗的价值和必要性。在慢性粒细胞白血病急变期，约三分之一的患者能够实现缓解。与其他肿瘤治疗形式一样，必须考虑初始状态、年龄和继发性疾病，并进行细致的个体化治疗规划。未来有望通过增加使原始细胞分化的可能性得出更系统的治疗结论。根据目前的知识，我们认为，实现长期缓解甚至治愈的最大希望在于骨髓移植。
