Metzner G, Fricke H J, Schröder D, Göring H D, Franke W, Karl M
Folia Haematol Int Mag Klin Morphol Blutforsch. 1983;110(4):526-39.
21 patients with diseases due to immunological causes were treated 6 times at an interval of four weeks by administering 5 E TF or 1 E TF each per 10 kg of body weight. TF consisted of 5 different large pool TF charges of 420 to 822 buffy-coats of fresh stored whole blood. Clinical and immunological investigations as well as biochemical ones in the laboratory were made before and after treatment. Large pool TF is clinically effective in 9 from 18 patients and immunologically in 16 from 18 patients. There is a greater effect in immunodeficiencies than in autoimmune diseases. TF is not able to remove the defect for a long time. Repeated administrations are required. TF therapy may be regarded as a substitution therapy. At first, the intervals have to be chosen according to clinical parameters (recidive of the disease or crisis respectively). There is a good compatibility of TF. Side-effects could not be observed. The frequent immunological conversions after score evaluation indicate, however, that in comparison to the clinical appearance the course of the disease must be seen to be much more complex than it can be expressed by in vitro correlates of immunological responses. Statistically ensured correlations of single tests concerning the clinical course could also not be found. Large pool TF provides favourable conditions for controlled therapy trials in order to elucidate those findings of therapy which hitherto had been a subject of controversy (e.g. autoimmune diseases, tumours).
21例免疫性病因所致疾病患者，每10kg体重每次给予5个E TF或1个E TF，每隔四周治疗1次，共治疗6次。TF由5种不同的大库TF制剂组成，来源于420至822份新鲜储存全血的血沉棕黄层。治疗前后进行了临床、免疫学及实验室生化检查。大库TF对18例患者中的9例临床有效，对18例患者中的16例免疫学有效。免疫缺陷疾病患者的疗效优于自身免疫性疾病患者。TF不能长期消除缺陷，需要重复给药。TF治疗可视为替代疗法。起初，给药间隔必须根据临床参数（疾病复发或危机情况）来选择。TF具有良好的耐受性，未观察到副作用。然而，评分评估后频繁的免疫转化表明，与临床表现相比，疾病的病程比免疫反应的体外相关性所表达的要复杂得多。也未发现关于临床病程的单项检测在统计学上有可靠的相关性。大库TF为对照治疗试验提供了有利条件，以便阐明那些迄今为止一直存在争议的治疗结果（如自身免疫性疾病、肿瘤）。
