Okada S, Suzuki M, Ohba H
J Inorg Biochem. 1983 Oct;19(2):95-103. doi: 10.1016/0162-0134(83)85015-6.
The effect of Cr(III) administration on hepatic RNA synthesis in mice was studied. It was found that Cr accumulated in mouse liver. Forty-eight hours after intraperitoneal injection of CrCl3 (0.005-5 mg Cr/kg body weight) approximately 10% of the administered dose per g of tissue remained. The accumulated Cr was still retained 64 days after administration (5 mg Cr/kg) with only a slight decrease. Approximately 20% of the hepatic Cr was detected in the nuclei. By administering CrCl3. RNA synthesis in mouse liver was markedly enhanced without altering the pool size of nucleotides. This enhancement was dose-dependent and statistically significant at doses of 0.05 (p less than 0.05), 0.5 (p less than 0.01), and 5 mg Cr/kg (p less than 0.01), and remained so for at least 16 days after administration of 5 mg Cr/kg. The synthesis of DNA and protein in mouse liver were not significantly changed by CrCl3 administration. On the other hand, Cr(VI) administration did not enhance but rather inhibited RNA synthesis in mouse liver. These results suggest that Cr(III) specifically enhances RNA synthesis in mouse liver.
研究了给予三价铬（Cr(III)）对小鼠肝脏RNA合成的影响。发现铬在小鼠肝脏中蓄积。腹腔注射氯化铬（CrCl3，0.005 - 5毫克铬/千克体重）48小时后，每克组织中约10%的给药剂量残留。给药（5毫克铬/千克）64天后，蓄积的铬仍有残留，只是略有减少。在细胞核中检测到约20%的肝脏铬。通过给予氯化铬，小鼠肝脏中的RNA合成显著增强，而核苷酸池大小未改变。这种增强呈剂量依赖性，在0.05（p < 0.05）、0.5（p < 0.01）和5毫克铬/千克（p < 0.01）剂量下具有统计学意义，并且在给予5毫克铬/千克后至少16天内一直如此。给予氯化铬后，小鼠肝脏中的DNA和蛋白质合成没有显著变化。另一方面，给予六价铬（Cr(VI)）并没有增强而是抑制了小鼠肝脏中的RNA合成。这些结果表明，三价铬特异性地增强了小鼠肝脏中的RNA合成。
