Effects of a prostaglandin I2 analogue, ZK 36374, on recurring reduction of coronary blood flow.

The effects of a stable prostaglandin I2 analogue, ZA 36374, on recurring reduction of blood flow in the partially constricted canine coronary artery were compared with those of prostaglandin I2. Intravenous bolus injections of 0.3 micrograms/Kg ZK 36374 and 0.15 micrograms/Kg prostaglandin I2 eliminated the recurring reductions. Intravenous infusion of 0.1 micrograms/Kg/min ZK 36374 and 0.01 micrograms/Kg/min prostaglandin I2 also eliminated the recurring reductions. The results indicate that although weaker than prostaglandin I2, ZK 36374 is effective in eliminating recurring reduction in coronary flow related to coronary vasospasm and/or thrombosis.