伊洛前列素（ZK 36374）可增强猪冠状动脉闭塞后再灌注期间局部心肌功能的恢复。
Iloprost (ZK 36374) enhances recovery of regional myocardial function during reperfusion after coronary artery occlusion in the pig.
作者信息
van der Giessen W J, Schoutsen B, Tijssen J G, Verdouw P D
出版信息
Br J Pharmacol. 1986 Jan;87(1):23-7. doi: 10.1111/j.1476-5381.1986.tb10152.x.
Abstract
Ligation of the left anterior descending coronary artery in open-chest pigs for 20 min caused a complete loss of regional myocardial function, which did not recover during the first two hours of reperfusion. Infusion of the stable prostacyclin analogue Iloprost (100 ng kg-1 min-1) did not prevent the loss of systolic wall function during ischaemia. Recovery of regional myocardial function during the first two hours of reperfusion was enhanced to 40% of baseline by Iloprost. This effect of Iloprost cannot be explained by a decreased O2-demand during ischaemia or an enhanced recovery of myocardial ATP content.
摘要
在开胸猪身上结扎左冠状动脉前降支20分钟会导致局部心肌功能完全丧失，在再灌注的最初两小时内无法恢复。输注稳定的前列环素类似物伊洛前列素（100纳克/千克/分钟）并不能防止缺血期间收缩期壁功能的丧失。伊洛前列素可使再灌注最初两小时内局部心肌功能的恢复增强至基线的40%。伊洛前列素的这种作用无法用缺血期间氧需求的降低或心肌ATP含量恢复的增强来解释。
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