伊洛前列素（ZK 36374）可增强猪冠状动脉闭塞后再灌注期间局部心肌功能的恢复。
Iloprost (ZK 36374) enhances recovery of regional myocardial function during reperfusion after coronary artery occlusion in the pig.
作者信息
van der Giessen W J, Schoutsen B, Tijssen J G, Verdouw P D
出版信息
Br J Pharmacol. 1986 Jan;87(1):23-7. doi: 10.1111/j.1476-5381.1986.tb10152.x.
Abstract
Ligation of the left anterior descending coronary artery in open-chest pigs for 20 min caused a complete loss of regional myocardial function, which did not recover during the first two hours of reperfusion. Infusion of the stable prostacyclin analogue Iloprost (100 ng kg-1 min-1) did not prevent the loss of systolic wall function during ischaemia. Recovery of regional myocardial function during the first two hours of reperfusion was enhanced to 40% of baseline by Iloprost. This effect of Iloprost cannot be explained by a decreased O2-demand during ischaemia or an enhanced recovery of myocardial ATP content.
摘要
在开胸猪身上结扎左冠状动脉前降支20分钟会导致局部心肌功能完全丧失，在再灌注的最初两小时内无法恢复。输注稳定的前列环素类似物伊洛前列素（100纳克/千克/分钟）并不能防止缺血期间收缩期壁功能的丧失。伊洛前列素可使再灌注最初两小时内局部心肌功能的恢复增强至基线的40%。伊洛前列素的这种作用无法用缺血期间氧需求的降低或心肌ATP含量恢复的增强来解释。
相似文献
1
Iloprost (ZK 36374) enhances recovery of regional myocardial function during reperfusion after coronary artery occlusion in the pig.伊洛前列素（ZK 36374）可增强猪冠状动脉闭塞后再灌注期间局部心肌功能的恢复。
Br J Pharmacol. 1986 Jan;87(1):23-7. doi: 10.1111/j.1476-5381.1986.tb10152.x.
2
Reduction in infarct size by the prostacyclin analogue iloprost (ZK 36374) after experimental coronary artery occlusion-reperfusion.
Am Heart J. 1988 Mar;115(3):499-504. doi: 10.1016/0002-8703(88)90796-x.
3
Protective effect of a prostacyclin-mimetic on the ischaemic-reperfused rabbit myocardium.一种前列环素类似物对缺血再灌注兔心肌的保护作用。
J Mol Cell Cardiol. 1988 Dec;20(12):1095-106. doi: 10.1016/0022-2828(88)90590-1.
4
Beneficial effects of iloprost in the stunned canine myocardium.伊洛前列素对犬顿抑心肌的有益作用。
Circ Res. 1988 Feb;62(2):204-15. doi: 10.1161/01.res.62.2.204.
5
6
Effect of iloprost (ZK 36 374) on membrane integrity in ischemic rabbit hearts.伊洛前列素（ZK 36 374）对缺血兔心脏膜完整性的影响。
Biomed Biochim Acta. 1984;43(8-9):S155-8.
7
Iloprost inhibits neutrophil function in vitro and in vivo and limits experimental infarct size in canine heart.
Circ Res. 1987 May;60(5):666-73. doi: 10.1161/01.res.60.5.666.
8
[Effect of Iloprost (ZK 36 374) on hemodynamic parameters during kidney donor conditioning in animal experiments].[伊洛前列素（ZK 36 374）对动物实验中肾供体预处理期间血流动力学参数的影响]
Z Exp Chir Transplant Kunstliche Organe. 1987;20(5):264-8.
9
The effect of the stable prostacyclin analogue ZK 36374 on experimental coronary thrombosis in the pig.稳定前列环素类似物ZK 36374对猪实验性冠状动脉血栓形成的影响。
Thromb Res. 1984 Oct 1;36(1):45-51. doi: 10.1016/0049-3848(84)90375-x.
10
Early and late administration of a PGI2-analogue, ZK 36 374 (iloprost): effects on myocardial preservation, collateral blood flow and infarct size.前列环素类似物ZK 36 374（依洛前列素）的早期和晚期给药：对心肌保护、侧支血流和梗死面积的影响。
Cardiovasc Res. 1984 Mar;18(3):163-73. doi: 10.1093/cvr/18.3.163.
引用本文的文献
1
Discovery of a new function of cyclooxygenase (COX)-2: COX-2 is a cardioprotective protein that alleviates ischemia/reperfusion injury and mediates the late phase of preconditioning.环氧化酶（COX）-2新功能的发现：COX-2是一种心脏保护蛋白，可减轻缺血/再灌注损伤并介导预处理的晚期阶段。
Cardiovasc Res. 2002 Aug 15;55(3):506-19. doi: 10.1016/s0008-6363(02)00414-5.
2
Bisoprolol improves perfusion of ischaemic myocardium in anaesthetized pigs.比索洛尔可改善麻醉猪缺血心肌的灌注。
Br J Pharmacol. 1988 Oct;95(2):361-70. doi: 10.1111/j.1476-5381.1988.tb11654.x.
3
Coronary thrombolysis with and without nifedipine in pigs.
Basic Res Cardiol. 1988 May-Jun;83(3):258-67. doi: 10.1007/BF01907359.
4
Effects of iloprost (ZK 36374) on glutathione status during ischaemia and reperfusion of rabbit isolated hearts.伊洛前列素（ZK 36374）对兔离体心脏缺血再灌注期间谷胱甘肽状态的影响。
Br J Pharmacol. 1989 Oct;98(2):678-84. doi: 10.1111/j.1476-5381.1989.tb12643.x.
5
Effects of dilevalol in the anesthetized pig with a partially occluded coronary artery.
Cardiovasc Drugs Ther. 1990 Dec;4(6):1461-5. doi: 10.1007/BF02026492.
6
Beneficial effect of beraprost, a prostacyclin-mimetic agent, on post-hypoxic recovery of cardiac function and metabolism in rabbit isolated hearts.前列环素类似物贝拉前列腺素对兔离体心脏缺氧后心功能和代谢恢复的有益作用。
Br J Pharmacol. 1991 Dec;104(4):779-86. doi: 10.1111/j.1476-5381.1991.tb12506.x.
7
Iloprost. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in peripheral vascular disease, myocardial ischaemia and extracorporeal circulation procedures.伊洛前列素。对其药效学和药代动力学特性以及在周围血管疾病、心肌缺血和体外循环手术中的治疗潜力的综述。
Drugs. 1992 Jun;43(6):889-924. doi: 10.2165/00003495-199243060-00008.
本文引用的文献
1
The effects of alinidine, an N-allyl derivative of clonidine, on regional myocardial perfusion and performance in the pig with or without atrial pacing.可乐定的N-烯丙基衍生物阿利尼定对有或无心房起搏的猪的局部心肌灌注及性能的影响。
Eur J Pharmacol. 1980 Jun 27;64(4):209-20. doi: 10.1016/0014-2999(80)90228-9.
2
Simultaneous determination of myocardial adenine nucleotides and creatine phosphate by high-performance liquid chromatography.高效液相色谱法同时测定心肌腺嘌呤核苷酸和磷酸肌酸
J Chromatogr. 1982 Jun 11;230(1):131-6. doi: 10.1016/s0378-4347(00)81439-5.
3
Rebound recovery of myocardial creatine phosphate with reperfusion after ischemia.缺血后再灌注时心肌磷酸肌酸的反弹恢复。
Am Heart J. 1984 Dec;108(6):1594-7. doi: 10.1016/0002-8703(84)90735-x.
4
Salvage of ischemic myocardium by prostacyclin during experimental myocardial infarction.前列环素在实验性心肌梗死期间对缺血心肌的挽救作用。
J Am Coll Cardiol. 1983 Aug;2(2):279-86. doi: 10.1016/s0735-1097(83)80164-8.
5
The effect of the stable prostacyclin analogue ZK 36374 on experimental coronary thrombosis in the pig.稳定前列环素类似物ZK 36374对猪实验性冠状动脉血栓形成的影响。
Thromb Res. 1984 Oct 1;36(1):45-51. doi: 10.1016/0049-3848(84)90375-x.
6
Improved functional recovery of the isolated rat heart after 24 hours of hypothermic arrest with a stable prostacyclin analogue (ZK 36 374).使用一种稳定的前列环素类似物（ZK 36 374）进行24小时低温停搏后，离体大鼠心脏的功能恢复得到改善。
J Mol Cell Cardiol. 1983 Nov;15(11):789-92. doi: 10.1016/0022-2828(83)90338-3.
7
Prostacyclin--antiarrhythmic or arrhythmogenic? Comparison of the effects of intravenous and intracoronary prostacyclin and ZK36374 during coronary artery occlusion and reperfusion in anaesthetised greyhounds.
J Cardiovasc Pharmacol. 1983 Jul-Aug;5(4):557-67. doi: 10.1097/00005344-198307000-00008.
8
PGI2 prevents ischemia-induced alterations in cardiac catecholamines without influencing nerve-stimulation-induced catecholamine release in nonischemic conditions.前列环素可预防缺血引起的心脏儿茶酚胺改变，而不影响非缺血状态下神经刺激诱导的儿茶酚胺释放。
J Cardiovasc Pharmacol. 1982 Sep-Oct;4(5):741-8. doi: 10.1097/00005344-198209000-00008.
9
Beneficial effects of a new carbacyclin derivative, ZK 36 374, in acute myocardial ischemia.一种新的卡巴前列素衍生物ZK 36 374对急性心肌缺血的有益作用。
J Pharmacol Exp Ther. 1981 Oct;219(1):243-9.
10
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.一种利用蛋白质 - 染料结合原理对微克级蛋白质进行定量的快速灵敏方法。
Anal Biochem. 1976 May 7;72:248-54. doi: 10.1016/0003-2697(76)90527-3.
Zotero 插件