Nybäck H, Berggren B M, Hindmarsh T, Sedvall G, Wiesel F A
Psychiatry Res. 1983 Aug;9(4):301-8. doi: 10.1016/0165-1781(83)90003-3.
Computed tomography (CT) measures and cerebrospinal fluid (CSF) levels of the monoamine metabolites homovanillic acid (HVA), 3-methoxy-4-hydroxyphenylglycol (MHPG), and 5-hydroxyindoleacetic acid (5-HIAA) were determined in 43 healthy volunteers and in 26 patients with an acute psychosis of the schizophrenic type. There were no differences in the mean CSF levels of monoamine metabolites between the two groups. However, the patients had significantly wider lateral and third ventricles as compared to the volunteers. In the volunteers there were no significant correlations between ventricular sizes and monoamine metabolite levels, whereas in the patients a significant negative correlation was obtained between the size of the lateral ventricles and the levels of HVA and 5-HIAA in the CSF. These results may indicate that the enlargements of the brain ventricles found in a subgroup of schizophrenic patients may be associated with deficiencies in central monoamine transmission mechanisms.
在43名健康志愿者和26名精神分裂症类型急性精神病患者中，测定了计算机断层扫描（CT）测量值以及单胺代谢产物高香草酸（HVA）、3-甲氧基-4-羟基苯乙二醇（MHPG）和5-羟吲哚乙酸（5-HIAA）的脑脊液（CSF）水平。两组之间单胺代谢产物的平均脑脊液水平没有差异。然而，与志愿者相比，患者的侧脑室和第三脑室明显更宽。在志愿者中，脑室大小与单胺代谢产物水平之间没有显著相关性，而在患者中，侧脑室大小与脑脊液中HVA和5-HIAA水平之间存在显著负相关。这些结果可能表明，在一部分精神分裂症患者中发现的脑室扩大可能与中枢单胺传递机制的缺陷有关。
