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作为摇蚊种类（双翅目，摇蚊科）间免疫交叉反应基础的血红蛋白共同抗原决定簇：人与动物血清研究

Common antigenic determinants of haemoglobin as basis of immunological cross-reactivity between chironomid species (Diptera, Chironomidae): studies with human and animal sera.

作者信息

Baur X, Dewair M, Haegele K, Prelicz H, Scholl A, Tichy H

出版信息

Clin Exp Immunol. 1983 Nov;54(2):599-607.

PMID:6197219
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1535874/
Abstract

Chironomids, of which approximately 10,000 species exist, are reported to cause severe immediate type allergic diseases in man. In the present study, immunological cross-reactivity between 14 chironomid species from different continents was proven by RAST inhibition, double immunodiffusion and a new allergoprint technique, based upon PAGE separation of insect crude extracts. Using isolated chironomid haemoglobins and sera of sensitized persons, as well as rabbit antibodies against larval crude extract or against the haemoglobin fraction of Chironomus thummi, it could be proven that cross-reactivity derives at least predominantly from haemoglobin components with common antigenic determinants in the different species.

摘要

摇蚊约有10000个种类，据报道可在人类中引发严重的速发型变态反应性疾病。在本研究中，基于昆虫粗提物的聚丙烯酰胺凝胶电泳分离，通过放射变应原吸附试验抑制、双向免疫扩散及一种新的变应原印记技术，证实了来自不同大陆的14种摇蚊之间存在免疫交叉反应。利用分离出的摇蚊血红蛋白、致敏者血清以及针对摇蚊幼虫粗提物或摇蚊血红蛋白组分的兔抗体，可证明交叉反应至少主要源自不同种类中具有共同抗原决定簇的血红蛋白成分。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdfc/1535874/74b0cbb245c6/clinexpimmunol00152-0320-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdfc/1535874/23eae80fa9db/clinexpimmunol00152-0316-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdfc/1535874/8a0a1a1d02be/clinexpimmunol00152-0319-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdfc/1535874/0f320d90628a/clinexpimmunol00152-0319-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdfc/1535874/74b0cbb245c6/clinexpimmunol00152-0320-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdfc/1535874/23eae80fa9db/clinexpimmunol00152-0316-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdfc/1535874/8a0a1a1d02be/clinexpimmunol00152-0319-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdfc/1535874/0f320d90628a/clinexpimmunol00152-0319-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cdfc/1535874/74b0cbb245c6/clinexpimmunol00152-0320-a.jpg

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Common antigenic determinants of haemoglobin as basis of immunological cross-reactivity between chironomid species (Diptera, Chironomidae): studies with human and animal sera.作为摇蚊种类（双翅目，摇蚊科）间免疫交叉反应基础的血红蛋白共同抗原决定簇：人与动物血清研究
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本文引用的文献

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DISC ELECTROPHORESIS. II. METHOD AND APPLICATION TO HUMAN SERUM PROTEINS.圆盘电泳。II. 方法及其在人血清蛋白中的应用。
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Hypersensitivity to chironomids (non-biting midges): localization of the antigenic determinants within certain polypeptide sequences of hemoglobins (erythrocruorins) of Chironomus thummi thummi (Diptera).
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Hoppe Seylers Z Physiol Chem. 1968 Feb;349(2):197-210.
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A new and simple radioimmunoassay method for the determination of IgE.一种用于测定IgE的新型简易放射免疫测定方法。
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Nature genetic basis and evolution of the haemoblobin polymorphism in Chironomus.摇蚊血红蛋白多态性的自然遗传基础与进化
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