Glaser B M, Kalebic T, Garbisa S, Connor T B, Liotta L A
Ciba Found Symp. 1983;100:150-62. doi: 10.1002/9780470720813.ch10.
A retina-derived substance (or substances) has been identified that stimulates vascular endothelial cells to degrade three structural components of basement membrane: type IV collagen, fibronectin and laminin. In basement membrane surrounding existing blood vessels, endothelial cells stimulated in this way can presumably migrate through the resulting gaps and form new vascular sprouts. These events may therefore represent the earliest steps in the formation of new blood vessels.
一种（或多种）视网膜衍生物质已被鉴定出来，它能刺激血管内皮细胞降解基底膜的三种结构成分：IV型胶原、纤连蛋白和层粘连蛋白。在现有血管周围的基底膜中，以这种方式受到刺激的内皮细胞大概可以通过产生的间隙迁移并形成新的血管芽。因此，这些事件可能代表了新血管形成的最早步骤。
