Rojo J M, Ojeda G, Portolés M P
J Immunopharmacol. 1983;5(3):231-43. doi: 10.3109/08923978309039108.
Isoprinosine (50 mg/kg i.p.) increased the ear swelling reaction in mice sensitized with trinitro-chlorobenzene (picryl chloride) and challenged with the same agent. Enhancements were observed when the drug was administered either simultaneously to the sensitization or to the challenge with picryl chloride. Similar results were obtained when lymphoid cells from sensitized animals were transferred i.v. to normal animals which were then challenged with picryl chloride. Using the same cell transfer system, we found that treatment of cell donors with Isoprinosine (50 mg/kg/day, i.p.) counteracts the inhibition induced by cyclophosphamide. Isoprinosine (50 mg/kg/day, i.p.) inhibited also the generation of antigen-specific suppressor cells induced by picryl-sulfonic acid as shown by transfer to normal recipients of suppressor cells together with lymphoid cells from sensitized animals. These results indicate that Isoprinosine enhances normal contact sensitivity reactions and can counteract, under certain circumstances, antigen-specific as well as nonspecific immunosuppression.
异丙肌苷（腹腔注射50毫克/千克）增强了用三硝基氯苯（苦基氯）致敏并再次接触相同试剂的小鼠的耳部肿胀反应。当药物在致敏时或再次接触苦基氯时同时给药，均可观察到增强作用。当将致敏动物的淋巴细胞静脉注射到正常动物体内，然后用苦基氯进行攻击时，也获得了类似的结果。使用相同的细胞转移系统，我们发现用异丙肌苷（腹腔注射50毫克/千克/天）处理细胞供体可抵消环磷酰胺诱导的抑制作用。如将抑制细胞与致敏动物的淋巴细胞一起转移到正常受体中所示，异丙肌苷（腹腔注射50毫克/千克/天）也抑制了由苦味磺酸诱导的抗原特异性抑制细胞的产生。这些结果表明，异丙肌苷增强正常的接触敏感性反应，并且在某些情况下可以抵消抗原特异性以及非特异性免疫抑制。
