Portolés A, Ojeda G, Rojo J M, Portolés M P, Barasoain I
J Immunopharmacol. 1983;5(3):245-56. doi: 10.3109/08923978309039109.
In the present work the effect of Isoprinosine on the mitogenic responses of T and B lymphocytes has been studied. We have found that Isoprinosine can enhance in vitro the response to Concanavalin A. This enhancement was more apparent in cell cultures showing an initially low blastogenic response. In low responses artificially induced by treatments in vivo with cyclophosphamide, our results indicate that Isoprinosine, administered in vivo, does not enhance the response to Con A of treated mice. However, addition of Isoprinosine (75 micrograms/ml) to cultures of spleen cells from mice previously treated with cyclophosphamide enhanced the suppressed response up to normal levels. Neither in vivo nor in vitro Isoprinosine treatments increased the response of lymphocytes to lipopolysaccharide, but usually inhibited the blastogenesis of B cells.
在本研究中，已对异丙肌苷对T和B淋巴细胞有丝分裂反应的影响进行了研究。我们发现，异丙肌苷可在体外增强对刀豆球蛋白A的反应。这种增强在最初显示低增殖反应的细胞培养物中更为明显。在用环磷酰胺进行体内处理人工诱导的低反应中，我们的结果表明，体内给予异丙肌苷不会增强经处理小鼠对刀豆蛋白A的反应。然而，向先前用环磷酰胺处理的小鼠的脾细胞培养物中添加异丙肌苷（75微克/毫升）可将受抑制的反应增强至正常水平。无论是体内还是体外，异丙肌苷处理均未增加淋巴细胞对脂多糖的反应，但通常会抑制B细胞的增殖。
