Nelson R L, Wahner H W, Gorman C A
Ann Intern Med. 1978 Jan;88(1):41-4. doi: 10.7326/0003-4819-88-1-41.
Rectilinear scan findings were correlated with the surgically documented size, location, and histology of thyroid carcinoma in 67 patients. At the site of the carcinoma, 36 (54%) had hypofunction, associated with a palpable abnormality in all but one patient; 16 (24%) had an abnormality on palpation but not on scanning; 11 (16%) had both a normal clinical examination and a normal scan, associated with a benign abnormality in another part of the thyroid; and four (6%) had a patchy uptake. A literature review established that use of the gamma camera with pinhole collimator does not increase the specificity of carcinoma predictability, despite the enhanced sensitivity. The scan may still be used in evaluating the clinically solitary nodule that is not obviously malignant. However, unless that module is hyperfunctioning, clinical criteria rather than appearance of the scan should contribute most to the decision of whether to treat surgically.
对67例患者的直线扫描结果与手术记录的甲状腺癌大小、位置及组织学进行了相关性分析。在癌灶部位，36例（54%）功能减退，除1例患者外均伴有可触及异常；16例（24%）触诊有异常但扫描无异常；11例（16%）临床检查及扫描均正常，与甲状腺其他部位的良性异常有关；4例（6%）有斑片状摄取。文献综述表明，尽管使用针孔准直器的γ相机提高了敏感性，但并未提高癌预测的特异性。扫描仍可用于评估临床孤立性、无明显恶性表现的结节。然而，除非该结节功能亢进，否则临床标准而非扫描表现应在决定是否进行手术治疗中起主要作用。
