[市售丙种球蛋白制剂中甲型和乙型肝炎病毒抗原的抗体]
[Antibodies to hepatitis A and B viral antigens in commercial gamma-globulin preparations].
作者信息
Viazov S O, Doroshenko N V, Khatkevich S P, Reznikov Iu P, Minakova L V
出版信息
Vopr Virusol. 1983 Sep-Oct;28(5):542-5.
Radioimmunoassay was used to study the presence of antibodies to hepatitis A and B virus antigens in commercial gamma-globulin preparations produced in 20 towns of the USSR. Antibodies to hepatitis A virus were found in all gamma-globulin lots tested, their titres varying from 1:10 to 1:1000. Anti-HBs in titres from 1:1 to 1:32 were found only in 66% of the lots tested, being present in all the lots produced in Moscow and Gorkiy and only in half of the lots produced in Tashkent. Antibodies to HBcAg and HBeAg of hepatitis B virus were found in all the lots gamma-globulin tested, their titres falling within the range of 1:100 1:4000 (anti-HBc) and 1:32-1:64 (anti-HBe).
采用放射免疫分析法研究了苏联20个城镇生产的商用丙种球蛋白制剂中甲型和乙型肝炎病毒抗原抗体的存在情况。在所有检测的丙种球蛋白批次中均发现了甲型肝炎病毒抗体，其滴度从1:10到1:1000不等。仅在66%的检测批次中发现了滴度为1:1至1:32的抗-HBs，莫斯科和高尔基生产的所有批次中均有该抗体，而塔什干生产的批次中只有一半含有该抗体。在所有检测的丙种球蛋白批次中均发现了乙型肝炎病毒核心抗原和e抗原的抗体，其滴度范围为1:100至1:4000（抗-HBc）和1:32至1:64（抗-HBe）。
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