有机磷化合物皮蝇磷对家兔的致畸作用。
Teratogenic effects of the organophosphorus compound fenchlorphos in rabbits.
作者信息
Nafstad I, Berge G, Sannes E, Lyngset A
出版信息
Acta Vet Scand. 1983;24(3):295-304. doi: 10.1186/BF03546733.
Abstract
Fenchlorphos was administered orally in doses of 0, 12.5, 25 and 50 mg per kg to pregnant rabbits from day 6 to 18 of gestation. No effect on implantation efficacy, number of live fetuses, or fetal weight was observed. The incidence of major malformations such as cardiovascular and brain anomalies was, however, increased in the medicated groups. Major skeletal malformations were more frequent in the medicated groups; minor skeletal variation were about equal in all groups. Dose-relationship was observed for cardiovascular malformations and cerebellar hypoplasia.
摘要
在妊娠第6天至18天，给怀孕的兔子口服皮蝇磷，剂量分别为每千克0、12.5、25和50毫克。未观察到对着床效果、活胎数量或胎儿体重有影响。然而，用药组中心血管和脑部异常等主要畸形的发生率有所增加。用药组中主要骨骼畸形更为常见；所有组中轻微骨骼变异情况大致相同。观察到心血管畸形和小脑发育不全存在剂量关系。
相似文献
1
Teratogenic effects of the organophosphorus compound fenchlorphos in rabbits.有机磷化合物皮蝇磷对家兔的致畸作用。
Acta Vet Scand. 1983;24(3):295-304. doi: 10.1186/BF03546733.
2
[Severe bone malformations in fetal valproic acid disease].[胎儿丙戊酸疾病中的严重骨骼畸形]
An Esp Pediatr. 1993 Jul;39(1):19-21.
3
Anagyrine-induced congenital defects.
J Pediatr. 1988 Feb;112(2):331. doi: 10.1016/s0022-3476(88)80099-4.
4
Teratologic and other embryotoxic effects of beta-aminopropionitrile in rats.β-氨基丙腈对大鼠的致畸及其他胚胎毒性作用。
Teratology. 1974 Oct;10(2):165-72. doi: 10.1002/tera.1420100213.
5
Appendicular skeletal and visceral malformations induced by thalidomide in bonnet monkeys.
Teratology. 1973 Apr;7(2):151-9. doi: 10.1002/tera.1420070206.
6
Teratogenicity and embryotoxicity of orally administered fenchlorphos in blue foxes.蓝狐口服倍硫磷的致畸性和胚胎毒性
Acta Vet Scand. 1983;24(1):99-112. doi: 10.1186/BF03546761.
7
No risk from vitamin D in pregnancy.
Ann Intern Med. 1971 Nov;75(5):807-8. doi: 10.7326/0003-4819-75-5-807_2.
8
Inhalation teratology study on monochlorobenzene in rats and rabbits.
Toxicol Appl Pharmacol. 1984 Nov;76(2):365-73. doi: 10.1016/0041-008x(84)90018-8.
9
Mechanism of environmental agents by class associated with adverse female reproductive outcome.
Prog Clin Biol Res. 1984;160:237-48.
10
[Toxicity of cyolane].
Zhonghua Yu Fang Yi Xue Za Zhi. 1983 Jul;17(4):216-8.
引用本文的文献
1
Reproductive Toxicity Evaluation of Pestban Insecticide Exposure in Male and Female Rats.对雄性和雌性大鼠接触杀虫畏杀虫剂的生殖毒性评估。
Toxicol Res. 2008 Jun;24(2):137-150. doi: 10.5487/TR.2008.24.2.137. Epub 2008 Jun 1.
2
Teratogenic effects induced by chitosan oligosaccharide in Wistar female rat Rattus norvegicus.壳寡糖致 Wistar 雌性大鼠（Rattus norvegicus）致畸作用。
Environ Sci Pollut Res Int. 2018 Apr;25(10):9371-9379. doi: 10.1007/s11356-018-1199-8. Epub 2018 Jan 18.
3
Prenatal effects of trichlorfon on the guinea pig brain.
Arch Toxicol. 1986 May;59(1):30-5. doi: 10.1007/BF00263954.
4
Neurotoxic effects of prenatal trichlorfon administration in pigs.产前给猪施用敌百虫的神经毒性作用。
Acta Vet Scand. 1987;28(3-4):321-32. doi: 10.1186/BF03548600.
5
Cholinesterase activities in uterus of normal and fenchlorphos treated blue foxes (Alopex lagopus) during various reproductive states.正常及经倍硫磷处理的蓝狐（北极狐）子宫在不同生殖状态下的胆碱酯酶活性
Acta Vet Scand. 1988;29(1):117-23. doi: 10.1186/BF03548400.
本文引用的文献
1
Influence of symmetrical polychlorinated biphenyl isomers on embryo and fetal development in mice. I. Teratogenicity of 3, 3', 4, 4', 5, 5',-hexachlorobiphenyl.对称多氯联苯异构体对小鼠胚胎和胎儿发育的影响。I. 3, 3', 4, 4', 5, 5'-六氯联苯的致畸性。
Toxicol Appl Pharmacol. 1981 Nov;61(2):269-76. doi: 10.1016/0041-008x(81)90417-8.
2
Teratogenicity and embryotoxicity of orally administered fenchlorphos in blue foxes.蓝狐口服倍硫磷的致畸性和胚胎毒性
Acta Vet Scand. 1983;24(1):99-112. doi: 10.1186/BF03546761.
3
[Artificial insemination in the experimental rabbit].
Tierarztl Prax. 1976;4(3):401-10.
4
5
Isolation of organic anions by extraction with liquid anion exchangers and its application to micromethods for acetylcholinesterase and 4-aminobutyrate aminotransferase.
Eur J Biochem. 1978 Nov 2;91(1):215-22. doi: 10.1111/j.1432-1033.1978.tb20954.x.
6
Diagnosis of encephalitozoonosis: a simple method for collection of rabbit blood.
Lab Anim. 1979 Jul;13(3):207-8. doi: 10.1258/002367779780937744.
Zotero 插件