Teratogenic effects of the organophosphorus compound fenchlorphos in rabbits.
作者信息
Nafstad I, Berge G, Sannes E, Lyngset A
出版信息
Acta Vet Scand. 1983;24(3):295-304. doi: 10.1186/BF03546733.
Abstract
Fenchlorphos was administered orally in doses of 0, 12.5, 25 and 50 mg per kg to pregnant rabbits from day 6 to 18 of gestation. No effect on implantation efficacy, number of live fetuses, or fetal weight was observed. The incidence of major malformations such as cardiovascular and brain anomalies was, however, increased in the medicated groups. Major skeletal malformations were more frequent in the medicated groups; minor skeletal variation were about equal in all groups. Dose-relationship was observed for cardiovascular malformations and cerebellar hypoplasia.
摘要
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