O,O-二乙基-O-(3,5,6-三氯-2-吡啶基)硫代磷酸酯的大鼠尿液代谢物。
Rat urinary metabolites from O,O-diethyl-O-(3,5,6-trichloro-2-pyridyl) phosphorothioate.
作者信息
Bakke J E, Feil V J, Price C E
出版信息
J Environ Sci Health B. 1976;11(3):225-30. doi: 10.1080/03601237609372038.
PMID:61979
Abstract
Rats metabolized single oral doses of O,O-diethyl-O(3,5,6-trichloro-2-pyridyl-2,6-14C) phosphorothioate to at least six radiolabeled urinary metabolites. The urine contained about 90 percent of the dose. Three of these metabolites were identified as the glucuronide of 3,5,6-trichloro-2-pyridinol (80% the urinary 14C), a glycoside of 3,5,6-trichloro-2-pyridinol (4%), and 3,5,6-trichloro-2-pyridinol (12%).
摘要
大鼠口服单剂量的O,O-二乙基-O(3,5,6-三氯-2-吡啶基-2,6-¹⁴C)硫代磷酸酯后，可将其代谢为至少六种放射性标记的尿液代谢物。尿液中含有约90%的给药剂量。其中三种代谢物被鉴定为3,5,6-三氯-2-吡啶醇的葡糖醛酸苷（占尿液¹⁴C的80%）、3,5,6-三氯-2-吡啶醇的糖苷（4%）和3,5,6-三氯-2-吡啶醇（12%）。
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