前列腺素I2在人体血液中的稳定性。
Stability of prostaglandin I2 in human blood.
作者信息
Pifer D D, Cagen L M, Chesney C M
出版信息
Prostaglandins. 1981 Feb;21(2):165-75. doi: 10.1016/0090-6980(81)90135-0.
PMID:7012932
Abstract
Prostaglandin I2 (PGI2) is hydrolyzed more slowly in human plasma than in buffer at the same pH; this stabilization appears to be due to binding of PGI2 to albumin. The stability of the antiaggregatory potency of PGI2 is similar in human blood and in plasma buffered to pH 7.55. No measurable conversion of [3H]-PGI2 to radioactive or nonradioactive metabolites occurred during incubation with blood.
摘要
前列腺素I2（PGI2）在人体血浆中的水解速度比在相同pH值的缓冲液中更慢；这种稳定性似乎是由于PGI2与白蛋白结合所致。PGI2抗聚集效力的稳定性在人体血液和pH值为7.55的缓冲血浆中相似。在与血液孵育期间，未发生可测量的[3H]-PGI2向放射性或非放射性代谢物的转化。
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