微球栓塞法对暂时滞留于肝脏的物质的药代动力学及耐受性研究。
Studies in pharmacokinetics and tolerance of substances temporarily retained in the liver by microsphere embolization.
作者信息
Lindell B, Aronsen K F, Nosslin B, Rothman U
出版信息
Ann Surg. 1978 Jan;187(1):95-9. doi: 10.1097/00000658-197801000-00018.
Abstract
Earlier investigation has shown that a temporary arrest of arterial blood flow can be achieved by embolization with degradable microspheres. This study was made to investigate the change in pharmacokinetics, and drug tolerance which takes place when a substance is retained in the liver by a microsphere embolization. 14C-labelled inulin and 5-fluorouracil were studied. The administration of these substances with microspheres led to a delay in their systemic distribution. Furthermore there was an increased tolerance to 5-fluoro-uracil, probably due to a prolonged first pass effect when the substance was temporarily retained in the liver by a microsphere embolization.
摘要
早期研究表明，通过可降解微球栓塞可实现动脉血流的暂时阻断。本研究旨在探讨当一种物质通过微球栓塞滞留在肝脏时，药代动力学的变化以及药物耐受性。对14C标记的菊粉和5-氟尿嘧啶进行了研究。这些物质与微球一起给药导致其全身分布延迟。此外，对5-氟尿嘧啶的耐受性增加，这可能是由于当该物质通过微球栓塞暂时滞留在肝脏时首过效应延长所致。
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Studies in pharmacokinetics and tolerance of substances temporarily retained in the liver by microsphere embolization.微球栓塞法对暂时滞留于肝脏的物质的药代动力学及耐受性研究。
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