Tyler J D, Galli S J, Snider M E, Dvorak A M, Steinmuller D
J Exp Med. 1984 Jan 1;159(1):234-43. doi: 10.1084/jem.159.1.234.
The long-accepted notion that alloimmune cytolytic T cells (CTL) mediate transplantation immunity has recently been called into question. In order to ascertain directly whether alloimmune CTL can mediate destruction of foreign tissue, we tested the ability of mouse CTL expanded as cloned populations in vitro to destroy allogeneic skin in vivo. The results of these studies prove unequivocally that cloned Lyt-2+ CTL can perform this task in an immunologically specific, H-2-restricted, and dose-dependent fashion.
长期以来被广泛接受的同种异体免疫细胞毒性T细胞(CTL)介导移植免疫的观点最近受到了质疑。为了直接确定同种异体免疫CTL是否能介导外来组织的破坏,我们测试了在体外作为克隆群体扩增的小鼠CTL在体内破坏同种异体皮肤的能力。这些研究结果明确证明,克隆的Lyt-2+ CTL能够以免疫特异性、H-2限制性和剂量依赖性方式完成这项任务。