静脉注射Lyt-2+溶细胞性T淋巴细胞克隆诱导的同种异体肿瘤排斥反应。
Allogeneic tumor rejection induced by the intravenous injection of Lyt-2+ cytolytic T lymphocyte clones.
作者信息
Engers H D, Glasebrook A L, Sorenson G D
出版信息
J Exp Med. 1982 Oct 1;156(4):1280-5. doi: 10.1084/jem.156.4.1280.
Abstract
The in vivo activity of murine Lyt-2+ cytolytic T lymphocyte clones was assessed in a tumor allograft model system. Mice that had been sublethally irradiated 16 h previously were injected intraperitoneally with 131I-IUdR-labeled tumor cells. Simultaneously, various doses of four cytolytic T cell clones were injected intravenously and the mice monitored for tumor cell elimination by whole-body counting tecniques. These four clones had been selected on the basis of their ability to proliferate in response to alloantigens in the absence of added T cell growth factor(s). With two of the four clones tested, rapid elimination of tumor cells within the peritoneal cavity was observed, as early as 48 h after intravenous injection of the cloned T cells.
摘要
在肿瘤同种异体移植模型系统中评估了小鼠Lyt-2 + 细胞毒性T淋巴细胞克隆的体内活性。16小时前接受亚致死剂量照射的小鼠经腹腔注射131I-IUdR标记的肿瘤细胞。同时，静脉注射不同剂量的四种细胞毒性T细胞克隆，并通过全身计数技术监测小鼠肿瘤细胞的清除情况。这四种克隆是根据它们在无添加T细胞生长因子的情况下对同种抗原作出增殖反应的能力挑选出来的。在测试的四个克隆中的两个克隆中，早在静脉注射克隆T细胞后48小时就观察到腹腔内肿瘤细胞的快速清除。
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