Loveland B E, Hogarth P M, Ceredig R, McKenzie I F
J Exp Med. 1981 May 1;153(5):1044-57. doi: 10.1084/jem.153.5.1044.
The Ly phenotype of cells mediating skin graft rejection was determined using monoclonal anti-Lyt-1.1 and Lyt-2.1 antibodies in CBA mice that received CBA lymphoid cells from mice sensitized to C57BL/6; i.e., alloantigenic differences arising from the H-2 and non-H-2 loci. It was clear that graft rejection was due wholly to the presence of Lyt-1 cells in the inoculum and that Lyt-123 or Lyt-23 cells had no effect. Furthermore, no synergism was noted between Lyt-1 and Lyt-2 cells. In this model, both the cytotoxic T cell and cytotoxic lymphocyte precursors were shown to be Lyt-123 and these could be depleted from sensitized Lyt-1 populations that mediated graft rejection. Thus cytotoxic T cells are not responsible for skin graft rejection, but rather, this is mediated by an Lyt-1 cell. Whether this T cell is distinct from other Lyt-1 cells (T helper, T cells mediating delayed hypersensitivity) is not clear at present, but other evidence, and traditional concepts, link graft rejection and delayed type hypersensitivity as being different manifestations of the same mechanism.
在接受来自对C57BL/6致敏小鼠的CBA淋巴细胞的CBA小鼠中，使用单克隆抗Lyt-1.1和Lyt-2.1抗体确定介导皮肤移植排斥反应的细胞的Ly表型；即，由H-2和非H-2基因座产生的同种异体抗原差异。很明显，移植排斥完全是由于接种物中存在Lyt-1细胞，而Lyt-123或Lyt-23细胞没有作用。此外，未观察到Lyt-1和Lyt-2细胞之间的协同作用。在该模型中，细胞毒性T细胞和细胞毒性淋巴细胞前体均显示为Lyt-123，并且这些细胞可从介导移植排斥反应的致敏Lyt-1群体中耗尽。因此，细胞毒性T细胞不是皮肤移植排斥反应的原因，而是由Lyt-1细胞介导的。目前尚不清楚这种T细胞是否与其他Lyt-1细胞（T辅助细胞、介导迟发型超敏反应的T细胞）不同，但其他证据和传统概念将移植排斥反应和迟发型超敏反应联系起来，认为它们是同一机制的不同表现形式。
