Vayá A, Carratalá A, Martinez C, Aznar J
Nouv Rev Fr Hematol (1978). 1983;25(6):369-73.
A total of 200 cases of thalassaemia trait, 102 of F thalassaemia and 98 of A2 thalassaemia were studied, evaluating haematometric, and morphological aspects of both groups. Significantly higher values were found in F thalassaemia for PCV, MCV and MCH, with 33.5% of women and 52% of men being found anaemic in F thalassaemia and 45% of women and 62% of men in A2 thalassaemia. Asthenia was usually present in A2 thalassaemia more so in women 50.9% as compared to 25% in man. Only 4% of F thalassaemia carriers were affected by asthenia. Cholecystectomy had been performed on 10% of the A2 thalassaemia group and on 5% of the F thalassaemia thamia group. Both groups show a high proportion of red cells with basophilic stippling (80%), the groups being morphologically indistinguishable. Intrafamilial segregation of Hb F values affected 22% of families carriers of F thalassaemia, whereas only 8% of families carriers of A2 thalassaemia showed segregation of HbA2 values. The values obtained in this study were compared with those of other authors.
共研究了200例地中海贫血特征患者，其中102例为F地中海贫血，98例为A2地中海贫血，评估了两组患者的血液学和形态学方面。F地中海贫血患者的红细胞压积（PCV）、平均红细胞体积（MCV）和平均红细胞血红蛋白含量（MCH）值显著更高，F地中海贫血中33.5%的女性和52%的男性贫血，A2地中海贫血中45%的女性和62%的男性贫血。乏力在A2地中海贫血中较为常见，女性中占50.9%，男性中占25%。只有4%的F地中海贫血携带者受乏力影响。A2地中海贫血组10%的患者和F地中海贫血组5%的患者进行了胆囊切除术。两组嗜碱性点彩红细胞比例均较高（80%），两组在形态上无法区分。F地中海贫血携带者家庭中，Hb F值的家族内分离影响了22%的家庭，而A2地中海贫血携带者家庭中只有8%表现出HbA2值的分离。本研究所得结果与其他作者的结果进行了比较。
