Wex P, Ebner H, Dragojevic D
Thorac Cardiovasc Surg. 1983 Dec;31(6):346-51. doi: 10.1055/s-2007-1022016.
Multiple large and small emphysematous bullae were resected in 27 patients with chronic obstructive lung disease (COLD). Twenty-two patients were operated on one side, and 5 patients underwent bilateral consecutive operations. Twenty-five patients were male, 2 female, and they were between 22 and 67 years old (mean 49.5 years). All patients had a follow-up examination between 3 and 48 months postoperatively. As operative techniques, resection by means of a clamp, plication of cysts according to Nissen, resection with homologous dura plasty (7 patients) and pericardial plasty (7 patients) were used. In 19 patients preoperative and postoperative pulmonary function was compared. Functional improvement occurred in 17 patients - including all of the 5 bilateral procedures. Postoperative improvement was more pronounced with decreasing preoperative pulmonary function, measured as VC, RV, IGV and Raw. Partial pulmonary insufficiency could be improved in 9 patients and global pulmonary insufficiency was improved in 5. In 16 cases physical work capacity was increased. The hemodynamics of the pulmonary circulation were improved in all patients with increased preoperative pulmonary artery pressure (latent pulmonary hypertension in 7 patients, overt pulmonary hypertension in 5). FEV1 was least influenced by surgery, especially in patients more than 50 years old. The long-term prognosis, thus has to be judged cautiously. One patient died postoperatively (mortality 4%). The technique of dura and pericardial plasty, aiming at functional adaptation, is described. Sutures inverting or folding pulmonary tissue are avoided. The aspect of at least temporary (up to 3 years) functional improvement leads us to advocate the use of extended criteria of operability.
对27例慢性阻塞性肺疾病(COLD)患者切除了多个大小不等的气肿性大疱。22例患者接受单侧手术,5例患者接受双侧连续手术。患者中25例为男性,2例为女性,年龄在22至67岁之间(平均49.5岁)。所有患者在术后3至48个月进行了随访检查。作为手术技术,采用了钳夹切除、根据尼森法折叠囊肿、用同种硬脑膜成形术切除(7例)和心包成形术切除(7例)。对19例患者进行了术前和术后肺功能比较。17例患者肺功能得到改善,其中包括所有5例双侧手术患者。术前肺功能以肺活量(VC)、残气量(RV)、吸气中期流量(IGV)和气道阻力(Raw)衡量,术后改善程度随术前肺功能下降而更明显。9例患者的部分肺功能不全得到改善,5例患者的整体肺功能不全得到改善。16例患者的体力工作能力增强。所有术前肺动脉压升高的患者(7例潜在肺动脉高压,5例显性肺动脉高压)肺循环血流动力学均得到改善。第一秒用力呼气容积(FEV1)受手术影响最小,尤其是50岁以上的患者。因此,长期预后必须谨慎判断。1例患者术后死亡(死亡率4%)。描述了旨在功能适应的硬脑膜和心包成形术技术。避免采用翻转或折叠肺组织的缝合方法。至少有暂时(长达3年)功能改善这一情况使我们主张采用更广泛的手术适应症标准。