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The effects of mirex on the neonatal rat lens in vitro, with a comparison to kepone.

作者信息

Rogers J M

出版信息

Toxicol Lett. 1983 Sep;18(3):241-4. doi: 10.1016/0378-4274(83)90100-5.

DOI:10.1016/0378-4274(83)90100-5
PMID:6198784
Abstract

Lenses were removed from 12-day-old rats and incubated in medium containing 20 microM mirex. Lenses were removed from the medium at 2, 4, 6, and 8 h and assayed for K+ and Na+ concentrations and hydration. Mirex had no in vitro effect on these lens parameters compared to controls, and produced no changes in lens clarity. In contrast, incubation for 8 h in medium containing 20 microM kepone resulted in elevated lens Na+ and lower lens K+. Thus, cataracts induced by mirex in vivo are probably not due to a direct toxic effect on the lens.

摘要

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