Schoffeniels E
Arch Int Physiol Biochim. 1983 Sep;91(3):233-42.
Kinetic as well as thermodynamic considerations favour the idea that the change in sodium conductance explaining the action potential, must result from a bimolecular reaction system. The fact that thiamine phosphorylated derivatives are associated with the specific protein forming the sodium channel could well mean that these thiamine derivatives and more specifically thiamine triphosphate are directly involved in the conductance change.
动力学以及热力学方面的考虑都支持这样一种观点，即解释动作电位的钠电导变化必定源于一个双分子反应系统。硫胺素磷酸化衍生物与构成钠通道的特定蛋白质相关联，这一事实很可能意味着这些硫胺素衍生物，更具体地说是三磷酸硫胺素，直接参与了电导变化。
