S-腺苷甲硫氨酸和S-腺苷高半胱氨酸对人白细胞组胺释放的调节作用。

Modulation by S-adenosyl-methionine and S-adenosyl-homocysteine of the human leucocytes histamine release.

作者信息

Pacheco Y, Macovschi O, Biot N, Fonlupt P, Perrin-Fayolle M, Pacheco H

出版信息

Clin Allergy. 1984 Jan;14(1):37-43. doi: 10.1111/j.1365-2222.1984.tb02187.x.

DOI:10.1111/j.1365-2222.1984.tb02187.x

PMID:6199134

Abstract

Methylation of membrane phospholipids is an important stage in the process of histamine release. This methylation reaction can be modulated by S-adenosyl-methionine (SAM) as well as by S-adenosyl-homocysteine (SAH). The influence of SAM and of SAH upon the histamine release of leucocytes from asthmatic and normal subjects were compared. In concentration of 10(-4) M, SAM enhanced spontaneous and the specifically induced histamine release. In concentration of 10(-5) M SAM enhanced the histamine release only in normals. This phenomenon could indicate a deficit in methyl-transferase activity in the asthamatics. In concentration of 10(-4) M, SAH reduced spontaneous and specifically induced histamine release, having an effect comparable to that of 10(-4) M Theophylline.

摘要

膜磷脂的甲基化是组胺释放过程中的一个重要阶段。这种甲基化反应可由S-腺苷甲硫氨酸（SAM）以及S-腺苷同型半胱氨酸（SAH）调节。比较了SAM和SAH对哮喘患者和正常受试者白细胞组胺释放的影响。在10^(-4) M的浓度下，SAM增强了自发的和特异性诱导的组胺释放。在10^(-5) M的浓度下，SAM仅增强了正常人的组胺释放。这种现象可能表明哮喘患者甲基转移酶活性存在缺陷。在10^(-4) M的浓度下，SAH减少了自发的和特异性诱导的组胺释放，其作用与10^(-4) M氨茶碱的作用相当。