Hof H, Emmerling P
Chemotherapy. 1984;30(2):125-30. doi: 10.1159/000238258.
10 different strains of Listeria monocytogenes tested in vitro were found to be susceptible to rifampicin showing minimal inhibitory concentrations between 0.0075 and 0.06 microgram/ml. Mice infected with a virulent strain of L. monocytogenes were treated with this antibiotic. Bacterial counts rapidly declined. In dextran sulfate-treated animals, deprived of their macrophage system and consequently highly susceptible to Listeria infection, rifampicin was able to protect the animals. Furthermore, nude athymic mice, chronically infected with L. monocytogenes, were also nearly cured. A few remaining bacteria, however, started to multiply after cessation of therapy, so that a relapse was noted. Development of resistance of L. monocytogenes to rifampicin during treatment was not observed.
在体外测试的10种不同单核细胞增生李斯特菌菌株被发现对利福平敏感，其最低抑菌浓度在0.0075至0.06微克/毫升之间。用这种抗生素治疗感染了单核细胞增生李斯特菌强毒株的小鼠。细菌数量迅速下降。在硫酸葡聚糖处理的动物中，其巨噬细胞系统被破坏，因此对李斯特菌感染高度敏感，利福平能够保护这些动物。此外，长期感染单核细胞增生李斯特菌的无胸腺裸鼠也几乎被治愈。然而，停止治疗后，少数残留细菌开始繁殖，因此出现了复发。在治疗期间未观察到单核细胞增生李斯特菌对利福平产生耐药性。
