Hof H, Waldenmeier G
Institute of Hygiene and Microbiology, University of Würzburg.
Infection. 1988;16 Suppl 2:S171-4. doi: 10.1007/BF01639743.
The therapeutic activities of various antibiotics were evaluated in two murine models, i.e. the infection of normal mice as well as of nude mice. Coumermycin and rifampicin were the most active drugs, since not only inhibition of multiplication but also rapid elimination of Listeria monocytogenes could be achieved in normal and immunocompromised animals. Ampicillin was the most active beta-lactam antibiotic followed by azlocillin. The other beta-lactam antibiotics were definitely less active. The combination of ampicillin with gentamicin expressed no synergistic effect in vivo. Co-trimoxazole as well as ciprofloxacin were of moderate therapeutic value. The bacteriostatic drugs such as tetracycline and erythromycin were able to inhibit the bacterial multiplication in the normal mouse but not in the immunocompromised host. Thus an optimal drug for therapy of listeriosis does not yet exist.
在两种小鼠模型中评估了各种抗生素的治疗活性，即正常小鼠和裸鼠的感染模型。香豆霉素和利福平是活性最强的药物，因为在正常和免疫受损动物中不仅可以抑制单核细胞增生李斯特菌的繁殖，还能快速清除该菌。氨苄西林是活性最强的β-内酰胺类抗生素，其次是阿洛西林。其他β-内酰胺类抗生素的活性明显较低。氨苄西林与庆大霉素联合使用在体内未表现出协同作用。复方新诺明以及环丙沙星具有中等治疗价值。四环素和红霉素等抑菌药物能够抑制正常小鼠体内的细菌繁殖，但在免疫受损宿主中则不能。因此，治疗李斯特菌病的最佳药物尚未存在。
