钙离子和P物质对大鼠脑不同区域突触体（钙镁）ATP酶（EC 3.6.1.3）活性的影响。

Influence of Ca2+ and substance P on the (Ca Mg) ATPase (EC 3.6.1.3) activity of synaptosomes from different areas of rat brain.

作者信息

Lachowicz L, Janiszewska G, Wojtkowiak R

出版信息

Int J Biochem. 1984;16(3):337-40. doi: 10.1016/0020-711x(84)90109-5.

PMID:6199236

Abstract

The influence of SP in vitro on the (Ca Mg) ATPase activity of synaptosomes from cerebral cortex, hippocampus, midbrain and thalamus with hypothalamus of rats was studied. It was confirmed that SP increases the activity of the enzyme from hippocampus, midbrain and thalamus with hypothalamus. A condition of this stimulation is the maintenance of Ca2+ concentration between 1 and 2 X 10(-4) M. Ca2+ concentration above and below the optimal (0.2 mM), reduced the SP stimulation of (Ca Mg) ATPase activity.

摘要

研究了P物质（SP）体外对大鼠大脑皮层、海马、中脑、丘脑及下丘脑突触体（Ca Mg）ATP酶活性的影响。证实SP可增加海马、中脑、丘脑及下丘脑该酶的活性。这种刺激的一个条件是将Ca2+浓度维持在1至2×10（-4）M之间。高于和低于最佳浓度（0.2 mM）的Ca2+浓度，均会降低SP对（Ca Mg）ATP酶活性的刺激作用。