人B细胞刺激的人胎儿胸腺细胞中的RNA肿瘤病毒样颗粒。
RNA tumor virus-like particles in human fetal thymus cells stimulated by human B-cells.
作者信息
Ono A, Higashinakagawa T, Nakamura T, Kondo S, Saito H, Yoshimatsu H, Suzuki H, Munakata Y, Tsuchiya M
出版信息
Gan. 1983 Dec;74(6):802-5.
PMID:6199250
Abstract
Human fetal thymuses were investigated in a search for retroviruses. By electron microscopy, retrovirus-like particles were detected in the thymus cells only when they were cocultured with mitomycin C-treated human B-cells. Reverse transcriptase activity in the culture medium was found at a density of 1.15-1.17 g/cm3 in sucrose density gradients.
摘要
为寻找逆转录病毒，对人类胎儿胸腺进行了研究。通过电子显微镜观察，只有当胸腺细胞与丝裂霉素C处理过的人类B细胞共培养时，才在胸腺细胞中检测到类逆转录病毒颗粒。在蔗糖密度梯度中，培养基中的逆转录酶活性在密度为1.15 - 1.17 g/cm³时被发现。
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