Aldegunde M, Duran R, Fernandez Otero P, Marco J
Gen Pharmacol. 1984;15(1):59-61. doi: 10.1016/0306-3623(84)90082-x.
The effects of two doses of ethanol (2 and 4 g/kg, i.p.) on the concentration of catecholamines (noradrenaline and dopamine), serotonin and 5-hydroxyindoleacetic acid in various regions of the rat brain were studied. The ethanol administration of both doses induces a significant decrease in the levels of hypothalamic noradrenaline. Similarly, 5-hydroxyindoleacetic acid levels in the same region and hemispheres are increased. The high dose produces an elevation in the concentration of midbrain dopamine. It was concluded that the hypothalamus is the brain region most sensitive to the action of ethanol and the effect of this substance differs according to the brain area.
研究了两种剂量的乙醇（2克/千克和4克/千克，腹腔注射）对大鼠脑不同区域儿茶酚胺（去甲肾上腺素和多巴胺）、血清素和5-羟吲哚乙酸浓度的影响。两种剂量的乙醇给药均导致下丘脑去甲肾上腺素水平显著降低。同样，同一区域和半球的5-羟吲哚乙酸水平升高。高剂量使中脑多巴胺浓度升高。得出的结论是，下丘脑是对乙醇作用最敏感的脑区，且该物质的作用因脑区而异。
