Ethanol, monoamines, and affect.

Evidence suggests that ethanol self-administration is directly related to central norepinephrine (NE) activity and inversely related to central serotonin (5-HT) activity. Normal male volunteers participated in a placebo controlled crossover design to assess the effects of 1-tyrosine (TY) and 1-tryptophan (TP) (precursors of catecholamines and 5-HT, respectively) in combination with ethanol, on several neurobehavioral measures. Ethanol by itself produced negative effects on several dimensions of mood. Dysphoria was potentiated by TP in combination with ethanol and either unchanged or attenuated by the combination of TY and ethanol. Ethanol impaired verbal recall, and neither TP nor TY in combination with ethanol altered that impairment. The results are consistent with the hypothesis that 5-HT mediates some of the negative mood effects produced by ethanol or antagonizes some of its positive effects, while NE at least partly mediates ethanol's positive effects on mood. Ethanol's impairment of verbal memory appears to be mediated by mechanisms outside the monoamine systems.