磷酸二酯酶抑制剂 UK 14,275 对人体的变力作用。
The inotropic effects of UK 14,275, a phosphodiesterase inhibitor, in man.
作者信息
Jackson P G, Jackson G, Kitson D, Jewitt D E
出版信息
Br J Clin Pharmacol. 1978 Jan;5(1):7-11. doi: 10.1111/j.1365-2125.1978.tb01591.x.
Abstract
- UK 14,275 (Pfizer) an inotropic agent with cardiac phosphodiesterase inhibitory activity, was administered to ten healthy male volunteers. 2. The inotropic activity was assessed by non-invasive measurement of systolic time intervals (STI). 3. The compound had significant inotropic activity in the doses administered, as judged by the shortening of pre-ejection period (PEP), without any significant chronotropic activity. 4. The inotropic effect was abolished when measurements were repeated following beta-adrenoceptor blockade with oral propranolol. 5. The inotropic activity was compared to that of intravenous isoprenaline.
摘要
- UK 14,275（辉瑞公司生产）是一种具有心脏磷酸二酯酶抑制活性的强心剂，对10名健康男性志愿者进行了给药。2. 通过无创测量收缩期时间间期（STI）来评估强心活性。3. 从给药剂量来看，该化合物具有显著的强心活性，表现为射血前期（PEP）缩短，且无任何显著的变时活性。4. 口服普萘洛尔进行β-肾上腺素能受体阻滞之后重复测量时，强心作用消失。5. 将该强心活性与静脉注射异丙肾上腺素的强心活性进行了比较。
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本文引用的文献
1
The effect of epinephrine on adenosine 3', 5'-phosphate levels in the isolated perfused rat heart.肾上腺素对离体灌注大鼠心脏中3',5'-磷酸腺苷水平的影响。
Mol Pharmacol. 1965 Sep;1(2):168-77.
2
Systolic time intervals in heart failure in man.人类心力衰竭时的收缩期时间间期
Circulation. 1968 Feb;37(2):149-59. doi: 10.1161/01.cir.37.2.149.
3
True isovolumic contraction time. Its correlation with two external indexes of ventricular performance.
Am J Cardiol. 1970 Apr;25(4):434-42. doi: 10.1016/0002-9149(70)90010-x.
4
Effect of digitalis on systolic time intervals in heart failure.洋地黄对心力衰竭患者收缩期时间间期的影响。
Am J Med Sci. 1970 Jan;259(1):4-20. doi: 10.1097/00000441-197001000-00002.
5
Acute hemodynamic effects of dopamine in patients with shock.多巴胺对休克患者的急性血流动力学效应。
Circulation. 1971 Aug;44(2):163-73. doi: 10.1161/01.cir.44.2.163.
6
Clinical significance of positive inotropic action of digoxin in patients with left ventricular disease.地高辛正性肌力作用在左心室疾病患者中的临床意义。
Br Heart J. 1973 Sep;35(9):970-6. doi: 10.1136/hrt.35.9.970.
7
Dopamine--clinical uses of an endogenous catecholamine.多巴胺——一种内源性儿茶酚胺的临床应用。
N Engl J Med. 1974 Oct 3;291(14):707-10. doi: 10.1056/NEJM197410032911405.
8
Activation of adenyl cyclase by glucagon in cat and human heart.胰高血糖素对猫和人类心脏中腺苷酸环化酶的激活作用。
Circ Res. 1969 Feb;24(2):151-6. doi: 10.1161/01.res.24.2.151.
9
Effects of adrenergic receptor activation and blockade on the systolic preejection period, heart rate, and arterial pressure in man.肾上腺素能受体激活与阻断对人体收缩期射血前期、心率及动脉压的影响。
J Clin Invest. 1967 Nov;46(11):1704-14. doi: 10.1172/JCI105661.
10
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Lancet. 1974 Aug 17;2(7877):363-7. doi: 10.1016/s0140-6736(74)91754-1.
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