胃排空的个体差异对血浆普萘洛尔浓度变异性的影响。
Contribution of individual differences in gastric emptying to variability in plasma propranolol concentrations.
作者信息
Castleden C M, George C F, Short M D
出版信息
Br J Clin Pharmacol. 1978 Feb;5(2):121-2. doi: 10.1111/j.1365-2125.1978.tb01610.x.
Abstract
1 No correlation was found between the rate of gastric emptying and peak plasma propranolol concentrations in six hypertensive patients after single oral doses of 80 mg. 2 In four normal subjects given oral propranolol the peak plasma concentration was highest when a simultaneous injection of metoclopramide and lowest when propantheline was given. The mean time to peak was 1.5 h after metoclopramide, 2.8 h after normal saline and 4.5 h after propantheline. 3 Gastric emptying has some influence on the time of peak plasma propranolol concentrations but individual variation in its bioavailability is determined mainly by first-pass metabolism in the liver.
摘要
- 对6名高血压患者单次口服80毫克普萘洛尔后，未发现胃排空速率与血浆普萘洛尔峰值浓度之间存在相关性。2. 在4名口服普萘洛尔的正常受试者中，同时注射甲氧氯普胺时血浆峰值浓度最高，而给予丙胺太林时最低。甲氧氯普胺给药后达到峰值的平均时间为1.5小时，生理盐水给药后为2.8小时，丙胺太林给药后为4.5小时。3. 胃排空对血浆普萘洛尔峰值浓度出现的时间有一定影响，但其生物利用度的个体差异主要由肝脏的首过代谢决定。
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