血浆普萘洛尔浓度与红细胞沉降率。

The plasma propranolol concentrations after a single oral dose of 40 mg were measured in 25 patients with rheumatoid arthritis and compared with those of 16 patients with Crohn's disease from a previous study. Thirteen healthy volunteers were used as controls. 2. In both diseases some high and some low values occurred. This scatter did not correlate with any symptoms or biochemical or haematological data other than with the erythrocyte sedimentation rate (ESR). 3. Both sets of patients were therefore separated into two groups depending on whether or not their ESRs were above or below 20 mm/l h. In both diseases the plasma propranolol concentrations of the patients with a raised ESR were significantly higher than the controls as well as those of the low ESR group. 4. In rheumatoid arthritis the plasma propranolol concentrations of the patients with a low ESR did not differ from those of the controls, but in Crohn's disease they remained significantly higher. 5. In one patient with Crohn's disease there was a dramatic rise in propranolol concentrations during an exacerbation (ESR 91 mm/l h) compared with those during a remission (ESR 20 mm/l h). 6. A difference in smoking habits did not seem to have been responsible for the difference in plasma propranolol concentrations.

对25例类风湿关节炎患者单次口服40毫克普萘洛尔后的血浆普萘洛尔浓度进行了测定，并与之前一项研究中16例克罗恩病患者的浓度进行了比较。13名健康志愿者作为对照。
在这两种疾病中，都出现了一些高值和一些低值。这种离散情况除了与红细胞沉降率（ESR）外，与任何症状、生化或血液学数据均无关联。
因此，根据两组患者的红细胞沉降率是否高于或低于20毫米/小时，将两组患者分为两组。在这两种疾病中，红细胞沉降率升高的患者的血浆普萘洛尔浓度均显著高于对照组以及红细胞沉降率低的组。
在类风湿关节炎中，红细胞沉降率低的患者的血浆普萘洛尔浓度与对照组无差异，但在克罗恩病中，其浓度仍显著较高。
1例克罗恩病患者在病情加重期（红细胞沉降率91毫米/小时）与缓解期（红细胞沉降率20毫米/小时）相比，普萘洛尔浓度急剧上升。
吸烟习惯的差异似乎并非血浆普萘洛尔浓度差异的原因。

Plasma propranolol concentrations and the erythrocyte sedimentation rate.