5-氟尿嘧啶给药途径对其在血液和淋巴中浓度的影响。
Effect of route of administration of 5-fluorouracil on its concentration in blood and lymph.
作者信息
Thomas M
出版信息
Br J Cancer. 1978 Jan;37(1):105-8. doi: 10.1038/bjc.1978.15.
Abstract
The concentration of 5-fluorouracil (FU) in thoracic-duct lymph, portal-vein blood and peripheral arterial blood of beagle dogs was greater after administration into the submucosa of the stomach than after the bolus i.v. injection. The concentration of FU in thoracic-duct lymph, portal-vein blood and arterial blood was least following administration into the lumen of the stomach. The total FU recovered over 6 h from thoracic-duct lymph was compared following the three routes of administration and was found to be greatest following injection into the submucosa of stomach.
摘要
将5-氟尿嘧啶（FU）注入比格犬胃黏膜下层后，其胸导管淋巴液、门静脉血和外周动脉血中的浓度高于静脉推注后的浓度。将FU注入胃腔后，其胸导管淋巴液、门静脉血和动脉血中的浓度最低。比较了三种给药途径后6小时内从胸导管淋巴液中回收的总FU量，发现注入胃黏膜下层后回收量最大。
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