Yamada K, Murphy G P, Douglass H O
J Surg Oncol. 1979;11(4):341-9. doi: 10.1002/jso.2930110409.
Intramural injection of 20 muCi (2-14C) 5-fluorouacil (5-FU) into the gastric submucosa of dogs and baboons was employed to evaluate the kinetics of 5-FU distribution following this route of administration and to compare these results with those following intraluminal, intravenous, and local intraarterial injections. Measurements of radioactivity taken over a six-hour period after injections demonstrated that the greatest concentration of isotope in samples of gastric wall and perigastric lymph nodes was found after administration of the drug directly into the stomach wall. Clinical application of intramural injections of 5-FU into the stomach wall under direct gastroscopic visual control, may be worthy of trial in patients with gastric cancer.
将20微居里（2-14C）的5-氟尿嘧啶（5-FU）注入狗和狒狒的胃黏膜下层，以评估经此给药途径后5-FU分布的动力学，并将这些结果与腔内注射、静脉注射和局部动脉内注射后的结果进行比较。注射后六小时内对放射性的测量表明，将药物直接注入胃壁后，在胃壁和胃周淋巴结样本中发现同位素的浓度最高。在直接胃镜可视控制下将5-FU壁内注射到胃壁的临床应用，可能值得在胃癌患者中进行试验。
