Lamb J R, Feldmann M
Nature. 1984;308(5954):72-4. doi: 10.1038/308072a0.
The induction of T-cell responses involves the recognition of extrinsic antigen in association with antigens of the major histocompatibility complex (MHC), in mice and man, with different T cells recognizing antigen in association with either class I (H-2K/D, HLA-A, B, C) or class II (Ia, HLA-D/DR) MHC antigens. However, the requirement of MHC recognition in the induction of immunological tolerance remains ill defined. With human T helper clones recognizing synthetic peptides of influenza haemagglutinin (HA-1), we have investigated the nature of antigen-induced stimulation, and antigen-induced antigen-specific unresponsiveness, immunological tolerance. Tolerance is not due to cell death, as the cells remain responsive to interleukin-2 and is associated with the loss of T3 antigen from the cell surface. Using monoclonal antibodies to the non-polymorphic regions of human class II antigens to inhibit the induction of T-cell tolerance we report here that induction of tolerance requires the recognition of MHC antigens.
T细胞反应的诱导涉及与主要组织相容性复合体（MHC）抗原相关的外源性抗原的识别，在小鼠和人类中，不同的T细胞识别与I类（H-2K/D、HLA-A、B、C）或II类（Ia、HLA-D/DR）MHC抗原相关的抗原。然而，MHC识别在免疫耐受诱导中的需求仍不明确。利用识别流感血凝素（HA-1）合成肽的人T辅助细胞克隆，我们研究了抗原诱导的刺激以及抗原诱导的抗原特异性无反应性即免疫耐受的本质。耐受并非由于细胞死亡，因为这些细胞对白介素-2仍有反应，且与细胞表面T3抗原的丢失有关。我们使用针对人类II类抗原非多态性区域的单克隆抗体来抑制T细胞耐受的诱导，在此报告耐受的诱导需要MHC抗原的识别。
